The vision of the Scientific Centre of Excellence for Viral Immunology and Vaccines is to establish strong human resources and technological foundations for the further development of viral immunology and vaccinology in the Republic of Croatia. The Centre’s activities focus on research into the interactions between viruses and the host immune system, which represent a key requirement for the development of new and effective vaccines and viral vectors for potential prevention and treatment of infectious diseases and tumors. To ensure effective implementation, the scientific work is structured into connected activities that together form the Centre’s comprehensive research strategy.
In the initial stages, the research focuses on clarifying the role of newly discovered cytomegalovirus genes in viral pathogenesis and in the regulation of the host immune response. These findings provide a foundation for the further development of recombinant vaccines against various pathogens and tumors, using cytomegalovirus as a vector. In parallel, the biology of the mumps virus and its mutants is being studied with the aim of developing safer and more effective vaccines, including recombinant viruses with reduced neurovirulence. Since this research involves the design and construction of recombinant human viruses that cannot infect conventional laboratory mouse strains, humanized mouse models are used. These models enable the complete reconstitution of human haematopoiesis and, consequently, the characterization of human immune responses to microbial and tumor antigens. In addition, mouse models expressing human receptors for specific viruses are used to enable infection of animal models with those viruses.
Further research is directed towards the study of immune surveillance in humans, particularly in the context of hantavirus and hepatitis C virus infections. Special attention is given to the mechanisms that regulate immune responses and to the role of NK cells in early antiviral defence and the development of immunological memory. The research also aims to translate the acquired knowledge into clinical practice through the optimization of viral vaccine production and the development of new research tools and approaches, while strengthening the research capacities of the participating institutions.
The Centre’s research relies on modern technologies, including CRISPR/Cas systems, next-generation sequencing, and computational analyses, which enable a deeper understanding of molecular and immunological mechanisms. This approach creates opportunities for the development of new diagnostic, prophylactic, and therapeutic solutions, with particular emphasis on viral and tumor immunotherapy.
The final phase of the research focuses on the translation of scientific knowledge into clinical practice, including the development of new immunotherapeutic strategies, antibodies, advanced biopharmaceuticals, and improved production technologies. In this way, the Centre contributes to the development of innovative healthcare solutions and strengthens preparedness for future pandemics.
In addition to its scientific activities, the Centre makes a significant contribution to the development of research capacities through international cooperation, education, and the training of young scientists. Dissemination and knowledge-transfer activities support the practical application of results and encourage interdisciplinary collaboration. Particular attention is also devoted to creating an inclusive, equitable, and accessible environment for all participants.
